Synthesis and Anticancer and Antiviral Activities of C-2′-Branched ArabinonucleosidesArticle Published on 2022-10-192022-11-15 Journal: International Journal of Molecular Sciences [Category] 치료제, [키워드] accompanied activity Analysis anti-SARS-CoV-2 anti-tumor Antiviral antiviral activity Cell cell line Concentration coronavirus cytotoxicity Effect functional Generation time group growth HaCaT immortalized inhibitory activity investigated morphological changes MTT nucleoside nucleoside analogue outcome parameter photocatalytic thiol-ene reaction Reactions SAR SARS-CoV-2 SCC synthesis time-lapse imaging. tumor cells tumorous was obtained [DOI] 10.3390/ijms232012566 PMC 바로가기
The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway칸디다 알비 칸스 CDK8- 의존적 포스 포 단백체는 FLO8- 의존적 경로를 통한 균사 성장의 억압을 나타낸다.Research Article Published on 2022-01-042022-09-06 Journal: PLoS Genetics [Category] Communicable Disease, [키워드] acquisition activities Affect Amino acid amino acids analyses ATP Candida Candida albican Candida albicans Cdk8 cell interactions cellular conditions dead dependent on drug resistance functional growth hypha hyphal identify Immune cell Impact inactivation increased expression inhibited Interaction interactions involved leads mediator Mediator complex medium member metabolism modulate Morphological morphological changes morphology mutant Mutation nutrient pathway performed phenotype Phenotypes phosphoproteome phosphorylation site physiological promoted Protein Protein phosphorylation sites Rapid reduced regulate Regulation regulator replaced reveal Serine shown Steady state strain substrate target targets the strongest These data threonine Transcription transcription factor transcriptional transcriptomics variant virulence was used [DOI] 10.1371/journal.pgen.1009622 PMC 바로가기 [Article Type] Research Article
Raman spectroscopy: current applications in breast cancer diagnosis, challenges and future prospects Reviews Published on 2021-12-102022-10-05 Journal: British Journal of Cancer [Category] 바이오마커, [키워드] accompany Asymptomatic biochemical Breast cancer Cancer change death develop diagnosed Diagnosis disease early stages improvement in vivo information lack management molecular morphological changes outcome Patient probe Raman spectroscopy required Research Sensitivity and specificity survival tissue translational treated tumour [DOI] 10.1038/s41416-021-01659-5 [Article Type] Reviews
Changes in peripheral blood in SARS CoV-2 patients and its clinico-pathological correlation: A prospective cross-sectional studyArticle Published on 2021-12-012023-06-19 Journal: International journal of laboratory hematology [Category] MERS, SARS, [키워드] Clinical severity COVID-19 Cycle threshold value morphological changes peripheral blood smear. [DOI] 10.1111/ijlh.13720 PMC 바로가기
Medicines for Malaria Venture COVID Box: a source for repurposing drugs with antifungal activity against human pathogenic fungi말라리아 벤처 코비드 박스를위한 의약품 : 인간 병원성 곰팡이에 대한 항진균 활동을 가진 약물을 용도의 소스Research Article Published on 2021-11-082022-08-31 Journal: Memórias do Instituto Oswaldo Cruz [Category] MERS, SARS, 신약개발, 치료제, [키워드] affected Antibiotics antifungal activity antimalarial antitumor agent antitumor agents Antiviral Box caused cells Concentration COVID COVID Box Cryptococcus neoforman Cryptococcus neoformans cycloheximide cyclosporine drug Drug repurposing effective therapy evaluated fungal fungal infections fungi fungicidal fungicidal activity fungistatic Fusarium genetic disorder growth highlight Histoplasma Histoplasma capsulatum Immunosuppressant immunosuppressants impair inhibited malaria Medicine Medicines morphological change morphological changes morphology MOST Mycoses nervous system niclosamide not affected Paracoccidioides brasiliensis pathogenic pathogenic fungi Side effects tested treat [DOI] 10.1590/0074-02760210207 PMC 바로가기 [Article Type] Research Article
Electrical impedance tomography in pediatric patients with COVID-19, the first reportsCovid-19를 가진 소아 환자의 전기 임피던스 단층 촬영, 첫 번째 보고서Observational Study Published on 2021-11-082022-09-01 Journal: BMC Pulmonary Medicine [Category] Fulltext, MERS, 임상, 진단, [키워드] Chest Chest radiograph clinical study Computed tomography COVID-19 COVID-19 infection COVID-19 patients distribution electrical impedance Electrical impedance tomography evaluate hospital intensive care intensive care unit ionizing radiation Lung diseases mitigate MONITOR morphological change morphological changes no sedation noninvasive objective Patient patients pediatric pediatric cohort Pediatric intensive care Pediatric patient Pediatric patients positive Radiation radiological real time repeated Result Sedation submitted tested Thoracic tomography Ventilation ventilatory was used with COVID-19 [DOI] 10.1186/s12890-021-01716-y PMC 바로가기 [Article Type] Observational Study
Biodegradable Nanofibrous Membranes for Medical and Personal Protection Applications: Manufacturing, Anti-COVID-19 and Anti-Multidrug Resistant Bacteria EvaluationArticle Published on 2021-07-102022-10-30 Journal: Materials [Category] COVID-19, [키워드] activity alcohol analogues anti-COVID-19 nanofibers anti-multi-drug resistant bacterial nanofibers antimicrobial agent Antiviral antiviral action antiviral agent average Bacteria Bacterial biodegradable nanofibrous membrane changed characterized Compound Concentration condition Contact COVID-19 Effectiveness equipment evaluated fiber homogenous Hydrogen bond hydrophobic MDR membrane Microscope Morphological morphological changes multi-drug resistant protection PVA-ZnO or -CuO nanohybrids Resistant rupture SEM Strains Structure tested variety Viral proteins [DOI] 10.3390/ma14143862 PMC 바로가기 [Article Type] Article
Infectious Bronchitis Virus Infection Induces Apoptosis during Replication in Chicken Macrophage HD11 CellsArticle Published on 2017-07-262022-10-28 Journal: Viruses [Category] Coronavirus, [키워드] Activation Ammonium Analysis Apoptosis apoptosis induction apoptotic blocked bronchitis caspase Caspases caused Cell cells cellular chicken chicken macrophage chloride CPE Cytopathic effect Efficacy expression extrinsic pathway flow cytometry IBV IBV infection Immune cell immune cells Infection Infectious Bronchitis Virus inhibited inhibitory intrinsic Macrophage macrophage cell line mammalian cell mechanism morphological changes offer previous study primary cells Replication reported Research suggested viability virus replication was increased [DOI] 10.3390/v9080198 PMC 바로가기 [Article Type] Article